RESEARCH PROJECTS

Ongoing Projects*

*Unless indicated, all research project inquiries should be directed to research@borregohealth.org.

Cultural Pride Reinforcement for Early School Readiness (CPR4ESR):

Development of a Clinic-Based Literacy Program to Promote Cultural Pride and School Readiness in Early Childhood

 

Abstract:

 

Background: The Reach Out and Read (ROR) program is a national effort to promote early literacy, providing books and literacy advice at pediatric well-child visits, reaching a third of those living in poverty. Minority children disproportionately experience poverty and racial bias, both of which are linked to school failure, toxic stress, and health disparities.

 

Aims: This program aims to develop a clinic-based early literacy program that provides families with book sharing guidance and culture-specific books at well-child visits. Specifically, the program goal is to foster an increase in 1) parental delivery of cultural pride messages, 2) child cultural pride, 3) child health, and 4) child school readiness.

 

Methods: For parents who have consented to the study, pediatric well-child visits at two Borrego Health clinics will be accompanied by a 30-minute session with a researcher that includes a survey and handouts on cultural literacy. Parents will be randomized to receive either book for their children aged 6 months to 5 years to help with general literacy (i.e. books normally received as part of the ROR program), or books that feature cultural themes and messages.

 

Clinic Sites: Arlanza Family Health Center; Eastside Health Center, Bldg A

 

Time Period: July 2018 – Present

 

Community Partners and PIs: UCR (Ashaunta Anderson, MD, MPH, MS)

 

Funding Source: First Five

Completed Projects*​


*Unless indicated, all research project inquiries should be directed to research@borregohealth.org.

 

Assessing Barriers to Contraceptive Care Among Resettled Refugee Women: A Mixed-Methods Investigation of Disparities in Quality and Access

 

Abstract:

 

Background: The purpose of this study is to understand the unique needs and preferences of resettled refugee women for receiving reproductive healthcare, including family planning services, prenatal care, gynecological cancers, and maternal mental health.

 

Aims: The results of this study will be used to inform clinician training and initiatives to improve access to and quality of reproductive healthcare for resettled refugee women.

 

Methods: A 10-20-minute-long survey with approximately 200 resettled refugee women between the ages of 18 and 55.

 

Clinic Site: Centro Medico El Cajon; La Mesa Women’s Health and Wellness Center

 

Time Period: February 2019 – May 2019

 

Community Partners and PIs: University of California, San Diego (Morgen Chalmiers, MA)

 

Funding Source: Society of Family Planning

Mexican Migrant MSM, Sexual Networks, and Prevention Hotspots in San Bernardino County

 

Abstract:

 

Background: San Bernardino County has a high rate of migration of people from neighboring regions, including Los Angeles County. There are sparse data on the reasons for these migrations, especially for marginalized communities.

 

Aims: Study goals include a.) performing formative research examining the social and structural context of immigration, mobility, and HIV among Mexican and Central American migrant men who have sex with men (MSM) in San Bernardino, CA; b.) identifying, developing, and refining measures of migration that may predict reductions in risky sexual behavior and increased in HIV preventive care (e.g. PrEP); and c.) developing methods to characterize mobility and sexual network patterns for at-risk Mexican and Central American migrant MSM in the San Bernardino area.

 

Methods: Interviews with at least 20 MSM of Mexican or Central American origin who reside in San Bernardino to discuss their migration history; experiences with HIV; and sexual history.

 

Clinic Site: D Street Medical Center

 

Time Period: May 2018 – March 2019

 

Community Partners and PIs: UCSB (Susan Cassels, Ph.D., MPH)

 

Funding Source: PIMSA

Patient-Centered Medical Home as a Complex Health Intervention

 

Abstract:

 

Background: Despite financial and human capital investment in transforming primary care settings to deliver patient-centered coordinated care (Patient-Centered Medical Home), national evidence of the effectiveness of this care model, once it is delivered in real life, has been mixed and disappointing.

 

Aims: The purpose of this project is to conceptualize the Patient-Centered Medical Home (PCMH) model as a complex health intervention and evaluate the feasibility of novel data collection methods. The project will characterize the local context of service arrangements and other elements of PCMH. Borrego Health participating clinics and QI department leadership will receive customized tools and reports from the study team.

 

Methods: The information is gathered through document reviews, key informant interviews, and job shadowing. A total of 24 administrators, providers, staff, and patients will be invited to participate.

 

Clinic Sites: Eastside A, Desert Hot Spring Community Health Center, and Centro Medico Coachella

 

Time Period: September 2018 – August 2019

 

Community Partners and PIs: University of Southern California (Mónica Pérez Jolles, Ph.D.)

 

Funding Source: USC Keck School of Medicine and Suzanne Dworak-Peck School of Social Work

Phase II Trial of Tesamorelin for Cognition in Aging HIV-Infected Persons

Contact Rod Hagan at rhagan@borregohealth.org for inquiries on this study.

 

Abstract:

 

Background: HIV-associated neurocognitive disorders (HAND) remain highly prevalent (occurring in up to 50%), are disabling, and even the mildest form, asymptomatic neurocognitive impairment (ANI), bears a high risk of accelerated progression to symptomatic neurocognitive disability. Longitudinal neurocognitive trajectories are worse in aging HIV+ as compared to HIV negative individuals and that among HIV+, worse trajectories are seen in those with abdominal obesity, immune activation, inflammation, and metabolic disturbances. Novel therapies are available to decrease abdominal obesity and reduce systemic inflammation/immune activation.

 

Aims: This clinical is testing Egrifta as a treatment to improve brain function in HIV positive people with abdominal obesity, which increases the risk of impaired thinking. The central goals of this study are to 1) determine if reducing VAT, which we postulate will attenuate VAT-related inflammation, immune activation and metabolic disturbances as in other populations and/or 2) increasing IGF-1 neurotrophic hormone status, will improve neurocognitive scores in obese, virally suppressed HIV+ patients as occurs in HIV negative persons. The conceptual basis for the proposed study is related to the fact that tesamorelin (Tes) selectively reduces VAT and has independent neurotrophic effects via increases in insulin-like growth factor type 1 (IGF-1).

 

Methods: Participants are assigned to immediate versus deferred treatment with tesamorelin (Egrifta) for 6 months. There is no placebo. Participants’ memory and ability to solve problems are tested, and MRI images of their abdomen and brain before and at the completion of the 6-month period are captured.

 

Clinic Site: Stonewall Medical Center

 

Time Period: June 2016 – June 2019

 

Community Partners and PIs: University of California: San Diego (Ronald Ellis, MD, Ph.D.)

 

Funding Source: National Institute on Aging

Prior Experience with Dolutegravir-based Two-drug Regimen and Outcomes (PEDTRO): Motivation behind the use of DTG-based 2DRs for Treatment of HIV in the United States

Contact Rod Hagan at rhagan@borregohealth.org for inquiries on this study.

 

Abstract:

 

Background: In 2016 it was estimated that approximately 13,000 patients were receiving 2DR in the US. However, the current literature on the physician drivers for prescribing 2DR is sparse.

 

Aims: The study aims to evaluate if a two-drug regimen (2DR) comprising of only two antivirals can provide the required clinical efficacy of a three- or four-drug regimen whilst minimizing the toxicity associated with antiretroviral therapy.

 

Methods: To address the evidence gap, ViiV Healthcare has partnered with Borrego Health to conduct a retrospective review of chart data for patients prescribed a 2DR to understand motivations for physicians prescribing 2DR at a patient-specific level and 2DR patient characteristics. Approximately 20 HIV treatment sites in the US are participating. At each site, data will be abstracted from the medical records for an overall sample size of up to approximately 350 patients.

 

Clinic Site: Stonewall Medical Center

Time Period: May 2018 – August 2018

Community Partners and PIs: Adelphi (Jenna Roberts, Ph.D.)

Funding Source: Adelphi Group

BCHF is a Federally Qualified Health Center and a Federal Tort Claims Act Deemed organization. The Federal Government is the primary insurer.
2019 Borrego Community Health Foundation (Borrego Health). All Rights Reserved.